منابع مشابه
Gene therapy in heart failure.
With increasing knowledge of basic molecular mechanisms governing the development of heart failure (HF), the possibility of specifically targeting key pathological players is evolving. Technology allowing for efficient in vivo transduction of myocardial tissue with long-term expression of a transgene enables translation of basic mechanistic knowledge into potential gene therapy approaches. Gene...
متن کاملGene Therapy in Heart Failure
Gene Selection The first challenge in developing gene therapy as a treatment modality is the identification of a gene whose modification will lead to an improvement in the underlying pathophysiology that could translate into improved clinical outcomes. The expression of many hundreds of genes changes in the failing heart; some of these changes are beneficial while others confer negative effects...
متن کاملImmune-inflammatory activation in heart failure.
Despite being relatively recent, a growing and significant accumulation of experimental and clinical evidence has been observed that points to a gradual state of immune-inflammatory activation in patients with heart failure (HF). High levels of several cytokines are found in the circulation and cardiac muscle of individuals with HF, and invariably correlate with the severity of the disease. The...
متن کاملNovel approaches to heart rate modulation in chronic heart failure.
Copyright © Polskie Towarzystwo Kardiologiczne INTRODUCTION The most recent version of the European Society of Cardiology (ESC) Guidelines for the management of heart failure (HF) has introduced two important innovations for the medical treatment of chronic HF with reduced ejection fraction (EF): mineralo-corticoid receptor antagonists (MCRA) and the If channel blocker ivabradine have now a rec...
متن کاملMetabolic therapy for heart failure including diastolic heart failure
Cardiac energetic impairment is a feature of systolic heart failure irrespective of the underlying etiology, and the magnitude of this impairment is predictive of subsequent mortality. It is also a feature of other forms of heart muscle diseases including hypertrophic cardiomyopathy and heart failure with normal ejection fraction. While the adult heart normally uses predominantly free fatty aci...
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ژورنال
عنوان ژورنال: Congestive Heart Failure
سال: 2006
ISSN: 1527-5299,1751-7133
DOI: 10.1111/j.1527-5299.2006.04630.x